Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

This collection addresses a post-WWII shift in the hierarchy of scientific explanations, where the highest goal moves from reductionism towards some ...

This paper presents the case of the post-crisis discursive defence of shadow banking in the Netherlands to argue, first, that there is a need to dust off older elite theories and adapt them to post-democratic conditions where there are no widely shared ‘political formulas’ to secure mass support for elite projects. Second, that temporality should be taken more seriously; it is when stories fail that elite storytelling can be observed in practice. As new ‘political formulas’ are minted and become established, (...) elites can again hope to withdraw from the political scene and leave policy-making to the self-evidence of output legitimacy and/or the perpetuum mobile of There-Is-No-Alternative. This suggests that elite theory should replace an epochal reading of post-democracy with a more conjunctural one. (shrink)

This commentary examines Glenberg's characterization of “suppression” in light of negative priming and related phenomena. After offering a radically different slant on suppression, an attempt is made to weave this alternative version into Glenberg's provocative discussion of embodied memories.

The author offers a conceptual investigation of the tension between openness and protection in well-developed welfare states. Because of a combination of demographic tendencies and labor market shortages, a growing number of European welfare states is currently exploring market-led immigration policies. However, the level of protection these welfare states offer seems hard to reconcile with the low threshold markets that are needed to incorporate newcomers. The author argues that the “solution”lies not so much in a clear political choice for either (...) but rather in the coordinated institutionalization of differentiated citizenship rights. The author illustrates this case with examples taken from the Dutch context, claiming further that the particular combination of corporatist welfare arrangements and the tradition of lenient enforcement in the Netherlands provides a “natural”habitat for the kind of regime pluralism that differentiated citizenship requires. (shrink)

For the theorists of crisis, the revolutionary state comes into existence through violence, and due to its inability to provide an authoritative katechon (restrainer) against internal and external violence, it perpetuates violence until it self-destructs. Writing during extreme economic depression and growing social and political violence, the crisis theorists––Joseph de Maistre, Juan Donoso Cortés, and Carl Schmitt––each sought to blame the chaos of their time upon the Janus-faced postrevolutionary ideals of liberalism and socialism by urging a return to pre-revolutionary moral (...) and religious values. They are united by three counterrevolutionary principles, all of which are purported to remedy revolutionary violence: traditional constitutional fidelity, the philosophy of the decision, and opposition to bourgeois liberalism. This essay is followed by the first complete English translation and publication of Donoso’s letter of October 24, 1851, which contains Donoso’s only reference to the “discussing class,” a political entity later popularized by Schmitt in his 1922 work Political Theology. (shrink)

Since the late 1980s, social scientists have argued that advanced economies have undergone a process of financial concentration that is resulting in a growing unevenness of the accessibility of capital. Households, small and medium-sized businesses as well as non-standard economic activities have increasing difficulties in finding funds. There are both sound economic and compelling moral reasons to address this issue. In order to ensure a more equal accessibility of capital, the author proposes a mandatory levy on the surpluses of mainstream (...) pension funds to fund an alternative financial infrastructure as a first step to redressing unevenness. The underlying rationale is that “financial pluralism” is the key to a more even accessibility of capital. (shrink)

This massive two-volume reference presents a comprehensive selection of the most important works on the foundations of mathematics. While the volumes include important forerunners like Berkeley, MacLaurin, and D'Alembert, as well as such followers as Hilbert and Bourbaki, their emphasis is on the mathematical and philosophical developments of the nineteenth century. Besides reproducing reliable English translations of classics works by Bolzano, Riemann, Hamilton, Dedekind, and Poincare, William Ewald also includes selections from Gauss, Cantor, Kronecker, and Zermelo, all translated here (...) for the first time. (shrink)

Immanuel Kant's Critique of Pure Reason is widely taken to be the starting point of the modern period of mathematics while David Hilbert was the last great mainstream mathematician to pursue important nineteenth cnetury ideas. This two-volume work provides an overview of this important era of mathematical research through a carefully chosen selection of articles. They provide an insight into the foundations of each of the main branches of mathematics--algebra, geometry, number theory, analysis, logic and set theory--with narratives to show (...) how they are linked. Classic works by Bolzano, Riemann, Hamilton, Dedekind, and Poincare are reproduced in reliable translations and many selections from writers such as Gauss, Cantor, Kronecker and Zermelo are here translated for the first time. The collection is an invaluable source for anyone wishing to gain an understanding of the foundation of modern mathematics. (shrink)

From 802 to 811, we encounter several diplomatic missions beween Byzantium and the Carolingians with the scope to secure or confirm peace, although in 798 such an agreement had been reached. The real target behind such negotiations was a recognition of the coronation and imperial title of Charlemagne since 800, denied by Byzantium for years. It was only in 810 that Nicephorus I yielded due to military/ political difficulties in Northern Italy with Pepin/pippin, son of Charlemagne, and against the Bulgarians. (...) A treaty defined spheres of interest and Byzantine representatives acclaimed Charlemagne as basileus in 812. The present article tries to clarify the different stages and elements of the whole process. When the power of the Carolingian state diminished in the ongoing 9th century, Byzantium step by step deviated from full recognition of the Western emperor, a process clearly visible during the joint venture against Arab Bari from 869 to 871. An appendix deals with the question, if Empress Eirene had offered a kind of junior-emperorship to Charlemagne in 798/799, as already Paul Speck proposed more than forty years ago, without finding much approval. Now it seems probable that he was right. (shrink)